Best Female Lead movies of 2000s

Actors : Zoe Saldana, Anson Mount, Taryn Manning, Britney Spears,
Directors : Tamra Davis,

Three childhood best friends, and a guy they just met, take a road trip across the country, finding themselves and their friendship in the process.

Actors : Stockard Channing, Jean-Marie Lhomme, Kate Hudson, Naomi Watts,
Directors : James Ivory,

French vs. American social customs and behaviors are observed in a story about an American visiting her Frenchman-wed sister in Paris.

Actors : Yui Ichikawa, Chiharu Niiyama, Noriko Sakai, Kei Horie,
Directors : Takashi Shimizu,

As their curse spreads on all around, the ghosts find their chance to live once again through the pregnancy of a cursed woman.

Actors : Jamie Starr, Lukas Haas, Kim Basinger, Craig Sheffer,
Directors : Susan Montford,

Della Myers is an overwhelmed upper-middle-class housewife who lives in a large house in the suburbs with her twin children and her abusive husband, Kenneth. Kenneth lets Della know that he...

Actors : Bob Papenbrook, David Lodge, Joshua Seth, Lara Jill Miller,

Three different stories involving digital creatures collide together.

Actors : Maria Hofstätter, Christine Jirku, Viktor Hennemann, Georg Friedrich,
Directors : Ulrich Seidl,

In a suburb of Vienna during some hot summer days: A teacher who is in bondage to a sleazy pimp, a very importunate hitchhiker, a private detective on the run for some car vandals, a couple...

Actors : Nick Cannon, Forest Whitaker, Kim Basinger, Kelsey Grammer,
Directors : Mark Rydell,

Gambling addiction bring the stories of three otherwise unconnected people together as it destroys each of their lives.

Actors : James Frain, Ashley Judd, Stockard Channing, Natalie Portman,
Directors : Matt Williams,

A pregnant 17-year-old rebuilds her life after being abandoned by her boyfriend at a Wal-Mart in Sequoyah, Oklahoma.

Actors : Milla Jovovich, Sebastien Andrieu, Nick Chinlund, Cameron Bright,
Directors : Kurt Wimmer,

A beautiful hemophage infected with a virus that gives her superhuman powers has to protect a boy in a futuristic world, who is thought to be carrying antigens that would destroy all hemophages.

Actors : Alessandro Nivola, Abigail Breslin, Brittany Snow, Elisabeth Shue,
Directors : David M. Rosenthal,

A young girl who has been abandoned by her former-groupie mother informs a fading rock star that she is his daughter.

Actors : Nino Khomasuridze, Dinara Drukarova, Temur Kalandadze, Esther Gorintin,
Directors : Julie Bertuccelli,

The one joy in the lives of a mother and daughter comes from the regular letters sent to them from Paris from the family's adored son, Otar. When the daughter finds out that Otar has died ...

Actors : Claudia Gerini, Natalia Barcelò, Sergio Castellitto, Penélope Cruz,
Directors : Sergio Castellitto,

A destitute woman (Cruz) becomes involved with an upper-crust physician (Castellitto).

Actors : Mya, Portia de Rossi, Christina Ricci, Jesse Eisenberg,
Directors : Wes Craven,

A werewolf loose in Los Angeles changes the lives of three young adults who, after being mauled by the beast, learn they must kill it in order to avoid becoming werewolves themselves.

Actors : Marina Cacciotti, Maria Calì, Grazia Cesarini Sforza, Valeria De Franciscis,
Directors : Gianni Di Gregorio,

Gianni is a middle-aged man living in Rome with his imposing and demanding elderly mother. His only outlet from her and the increasing debt into which they are sinking, are the increasingly...

Actors : Scott Cohen, Lisa Kudrow, Natalie Portman, Charlie Tahan,
Directors : Don Roos,

The story of a woman dealing with her daughter's death while trying to keep her marriage and her relationship with her stepson.

Actors : Juliette Lewis, Jennifer Lopez, Billy Campbell, Tessa Allen,
Directors : Michael Apted,

After running away fails, a terrified woman (Jennifer Lopez) empowers herself in order to battle her abusive husband (Billy Campbell).

Actors : Georgia Groome, Aaron Taylor-Johnson, Karen Taylor, Alan Davies,
Directors : Gurinder Chadha,

The story centers on a 14-year-old girl who keeps a diary about the ups and downs of being a teenager, including the things she learns about kissing.

Actors : Elle Fanning, Patricia Clarkson, Felicity Huffman, Bill Pullman,
Directors : Daniel Barnz,

Confounded by her clashes with the seemingly rule-obsessed world, a troubled young girl seeks enlightenment from her unconventional drama teacher.

Actors : Amy Sedaris, Stephen Colbert, Paul Dinello, Paul Sedaris,
Directors : Paul Dinello,

A prequel to the critically acclaimed series featuring Jerri Blank, a forty-six-year-old ex-junkie, ex-con who returns to high school in a bid to start her life over.

Actors : Lucy Tulugarjuk, Fiona Gordon, Dominique Abel, Philippe Martz,

Fiona, Julien and their two clone-like children live a life appropriate to the robots they have become, in a style-less, cheerless suburb somewhere in the flatlands of French-speaking ...