Best Female Lead movies of 2000s

Actors : Jaya Bhaduri, Saif Ali Khan, Shah Rukh Khan, Preity Zinta,
Directors : Nikkhil Advani,

Naina, an introverted, perpetually depressed girl's life changes when she meets Aman. But Aman has a secret of his own which changes their lives forever. Embroiled in all this is Rohit, Naina's best friend who conceals his love for her.

Actors : Brett Jacobsen, Claire Sloma, Marlon Morton, Amanda Bauer,
Directors : David Robert Mitchell,

Four young people navigate the suburban wonderland of metro-Detroit looking for love and adventure on the last weekend of summer.

Actors : Katie Holmes, Anna Paquin, Josh Duhamel, Malin Akerman,
Directors : Galt Niederhoffer,

Seven close friends reunite for the wedding of two of their friends. Problems arise because the bride and the maid of honor have had a long rivalry over the groom.

Actors : Katie Holmes, Guy Pearce, Bailee Madison, Bruce Gleeson,
Directors : Troy Nixey,

A young girl sent to live with her father and his new girlfriend believes that she has released creatures from a sealed ash pit in the basement of her new home.

Actors : Columbus Short, Jay Hernandez, Steve Harris, Jennifer Carpenter,
Directors : John Erick Dowdle,

A television reporter and her cameraman are trapped inside a building quarantined by the CDC, after the outbreak of a mysterious virus which turns humans into bloodthirsty killers.

Actors : Rosemarie Bergmans, Julienne De Bruyn, Dora van der Groen, Ann Petersen,
Directors : Lieven Debrauwer,

Pauline is a 'little girl of 66 years old'. She is intellectually disabled and been cared after by her sister Martha. When Martha dies, her two younger sisters, Paulette and Cecile have to ...

Actors : Kendra C. Johnson, Jimmy Jean-Louis, Godfrey, Mo'Nique,
Directors : Nnegest Likké,

Two plus-sized ladies meet the men of their dreams in the most unexpected of ways.

Actors : Joy Bryant, Gena Rowlands, Peter Sarsgaard, Kate Hudson,
Directors : Iain Softley,

A hospice nurse working at a spooky New Orleans plantation home finds herself entangled in a mystery involving the house's dark past.

Actors : Kathy Bates, Alfre Woodard, Sanaa Lathan, Rockmond Dunbar,
Directors : Tyler Perry,

Two families from different walks of life learn to work together.

Actors : Fumiko Orikasa, Shôzô Îzuka, Miyoko Shôji, Mami Koyama,
Directors : Satoshi Kon,

A TV interviewer and his cameraman meet a former actress and travel through her memories and career.

Actors : Michael Ealy, Courteney Cox, Dori Mizrahi, James Le Gros,
Directors : Greg Harrison,

Sophie Jacobs is going through the most difficult time of her life. Now, she just has to find out if it's real.

Actors : Samuel L. Jackson, Justin Timberlake, Christina Ricci, S. Epatha Merkerson,
Directors : Craig Brewer,

A God-fearing bluesman takes to a wild young woman who, as a victim of childhood sexual abuse, looks everywhere for love, never quite finding it.

Actors : Sibel Kekilli, Settar Tanriögen, Derya Alabora, Nizam Schiller,
Directors : Feo Aladag,

Umay is a young woman of Turkish descent, fighting for an independent and self-determined life in Germany against the resistance of her family. Her struggle initiates a dynamic, which results in a life-threatening situation.

Actors : Anna Paquin, Giancarlo Giannini, Lena Olin, Iain Glen,
Directors : Jaume Balagueró,

A teenage girl moves into a remote countryside house with her family, only to discover that their gloomy new home has a horrifying past that threatens to destroy the family.

Actors : Rip Torn, Dina Korzun, Darren E. Burrows, Andrew Lawrence Henderson,
Directors : Ira Sachs,

A Russian woman living in Memphis with a much older rock-'n'-roll legend experiences a personal awakening when her husband's estranged son comes to visit.

Actors : Sami Bouajila, Sotigui Kouyaté, Roschdy Zem, Brenda Blethyn,
Directors : Rachid Bouchareb,

Two strangers come to discover the fate of their respective children in the 2005 terrorist attacks on London.

Actors : Amy Brenneman, Kathy Baker, Hugh Dancy, Maria Bello,
Directors : Robin Swicord,

Six Californians start a club to discuss the works of Jane Austen, only to find their relationships -- both old and new -- begin to resemble 21st century versions of her novels.

Actors : Aitana Sánchez-Gijón, Dino Abbrescia, Giorgio Careccia, Riccardo Zinna,
Directors : Gabriele Salvatores,

A young boy accidentally discovers a deep hole in the ground, where another boy is kept prisoner.

Actors : Bruno Cremer, Charlotte Rampling, Jacques Nolot, Alexandra Stewart,
Directors : François Ozon,

When her husband goes missing at the beach, a female professor begins to mentally disintegrate as her denial of his disappearance becomes delusional.

Actors : Nick Stahl, Deborra-Lee Furness, AnnaSophia Robb, Charlize Theron,
Directors : Bill Maher,

The drama follows a 12-year-old girl's struggle to come to terms with her mother's abandonment.