A British medical doctor fights a cholera epidemic in a small Chinese village, while being trapped at home in a loveless marriage to an unfaithful wife.
In a future world devastated by disease, a convict is sent back in time to gather information about the man-made virus that wiped out most of the human population on the planet.
The exiled royal physician to King Charles II devotes himself to helping Londoners suffering from the plague, and in the process falls in love with an equally poor woman.