On a journey to find the cure for a Tatarigami's curse, Ashitaka finds himself in the middle of a war between the forest gods and Tatara, a mining colony. In this quest he also meets San, the Mononoke Hime.
A young man kills his bride on the day of his marriage and goes insane. He wakes up in an asylum with no memory, left in the hands of two mysterious doctors who relate his condition with his biological identity.