A special military unit fights a powerful, out-of-control supercomputer and hundreds of scientists who have mutated into flesh-eating creatures after a laboratory accident.
Alice awakes in Raccoon City, only to find it has become infested with zombies and monsters. With the help of Jill Valentine and Carlos Olivera, Alice must find a way out of the city before it is destroyed by a nuclear missile.
While still out to destroy the evil Umbrella Corporation, Alice joins a group of survivors living in a prison surrounded by the infected who also want to relocate to the mysterious but supposedly unharmed safe haven known only as Arcadia.
Alice fights alongside a resistance movement to regain her freedom from an Umbrella Corporation testing facility.