Spoiled by their upbringing and unaware of what wildlife really is, four animals from the New York Central Zoo escape, unwittingly assisted by four absconding penguins, and find themselves in Madagascar.
The animals try to fly back to New York City, but crash-land on an African wildlife refuge, where Alex is reunited with his parents.
After moving his family back to his hometown to be with his friends and their kids, Lenny finds out that between old bullies, new bullies, schizo bus drivers, drunk cops on skis, and 400 costumed party crashers sometimes crazy follows you.