After a family tragedy, three generations of the Deetz family return home to Winter River. Still haunted by Beetlejuice, Lydia's life is turned upside down when her teenage daughter, Astrid, accidentally opens the portal to the Afterlife.
Liza dreams of a better life for her and her daughter so she gets a job at a bankrupt pharmacy and Liza's guts catapult the company and her into the high life not knowing that she will soon be in the middle of a criminal conspiracy.